Peer-Reviewed Clinical Evidence

Science & Research

Bioactive Precision Peptides™ are AI-discovered, plant-derived peptides backed by 18+ randomized, double-blind, placebo-controlled clinical trials published in peer-reviewed journals.

7,000+
Peptides found in the human body
18+
Peer-reviewed clinical studies
10×
Faster discovery than traditional methods
600×
More accurate via AI-driven identification

AI-Driven Peptide Discovery

MAKE Wellness uses a proprietary machine learning platform to identify bioactive peptides from natural plant sources — 10× faster and 600× more accurate than traditional discovery methods. The AI screens thousands of natural compounds, applies biochemical filters, and validates candidates through a rigorous 6-step process before any human trial begins.

Peptides are information carriers — they carry biological information from one cell to another for everything in the body to function correctly. At least 7,000 peptides are found in the human body, and DNA itself is a matrix of inactive information waiting for peptides to deliver up-regulating or down-regulating messages to genes.

The 6-Step Discovery Process
  1. 1
    Understand: Determine required biochemical pathways
  2. 2
    Identify: Screen for the most effective peptides in nature
  3. 3
    Refine: Apply filters to select the best peptides
  4. 4
    Confirm: Produce a sample and test on cells
  5. 5
    Validate: Unlock the natural network and test on humans
  6. 6
    Produce: Patent and produce peptides formulated with synergistic co-factors

The Five Formulas — Mechanisms & Efficacy

Each formula targets a distinct biological pathway. Click any card to expand the full mechanism and clinical benefit breakdown.

Formula
FIT
Muscle Preservation & Recovery
54.3%
Reduction in lean muscle loss
144%
Increase in strength recovery rate
47%
Reduction in muscular fatigue
54%
Increase in performance
Formula
LEAN
Fat Loss & Metabolic Health
100%
Weight loss from fat mass (CT documented)
6%
Reduction in fat mass
2 in.
Waist circumference reduction
65%
Fat loss from trunk area
Formula
ENERGIZED
Sustained Energy & Vitality
95%
Confidence interval in RCTs
Serotonin & dopamine levels
0
Jitters — sustained release formula
Mental fatigue & cortisol
Formula
FOCUSED
Cognitive Performance & Neuroprotection
Cerebral blood flow
BDNF — neuronal health
Oxidative stress
Memory & processing speed
Formula
HYDRATED
Electrolyte & Peptide Support
6
Electrolyte pathways supported
Peptide bioavailability
Muscle & nerve function
Full-stack absorption

Peer-Reviewed Clinical Studies

All human trials listed are randomized, double-blind, and placebo-controlled unless otherwise noted. Full protocols, participant numbers, endpoints, and p-values are available upon request.

Key Researchers

The science behind Bioactive Precision Peptides™ is authored by a team of PhDs and AI researchers whose combined work spans peptide biochemistry, clinical nutrition, machine learning, and pharmaceutical formulation.

NK
Dr. Nora Khaldi
Chief Science Officer, MAKE Wellness
AI / Machine LearningPeptide DiscoveryComputational Biology
Founder, Nuritas Ltd.

Dr. Nora Khaldi founded Nuritas, a world-leading AI-driven bioactive peptide discovery company, and serves as Chief Science Officer at MAKE Wellness. Her proprietary machine learning platform screens thousands of natural plant compounds to identify novel bioactive peptides at 10× the speed and 600× the accuracy of traditional discovery methods.

Dr. Khaldi's platform applies a rigorous 6-step process — from biochemical pathway mapping through cell-level confirmation to human clinical validation — before any peptide enters a MAKE Wellness formula. Her work has been published in leading peer-reviewed journals and has attracted investment from some of the world's largest food and pharmaceutical companies.

10× faster
Discovery Speed
600× more accurate
Identification Accuracy
Thousands
Natural Sources Screened
Human RCTs
Validation Standard
MB
Mark Bartlett, PhD
Lead Formulation Scientist
MAKE Wellness
Clinical NutritionPeptide FormulationmTOR Pathways

Dr. Bartlett is the primary author of the MAKE Wellness clinical research reviews, including the peer-reviewed 'Fit with Peptistrong Plus' and 'Lean with Apticurb Trimfast Complex' papers. His work focuses on translating AI-discovered peptide candidates into clinically validated nutritional formulations, with a particular emphasis on mTOR activation, myostatin inhibition, and metabolic pathway modulation.

Key Publications
  • Fit with Peptistrong Plus — Clinical Review
  • Lean with Apticurb Trimfast Complex — Clinical Review
  • BPP: A New Class of Clinically Validated Nutritional Therapeutics
AJ
Alan Jones, PhD
Clinical Research Scientist
MAKE Wellness
Metabolic HealthFat Loss ScienceGut-Brain Axis

Dr. Jones specializes in the metabolic and lipolytic mechanisms underlying the LEAN and ENERGIZED formulas. His research examines how bioactive peptides modulate the gut-brain axis — regulating ghrelin, leptin, and NPY — to produce clinically measurable reductions in fat mass without lean muscle loss. He co-authored the BPP clinical studies summary covering 18 randomized controlled trials.

Key Publications
  • BPP Studies: A New Class of Clinically Validated Nutritional Therapeutics
  • Metabolic Modulation via Gut-Brain Axis Peptides
  • Lipolysis Enhancement Through Bioactive Peptide Pathways
JM
Jen Milks, PhD, MBA
Scientific Communications Lead
MAKE Wellness
Clinical EducationPharmacy ScienceBiochemistry

Dr. Milks bridges the gap between complex peptide biochemistry and pharmacy-level clinical education. She authored the comprehensive 'Bioactive Precision Peptides — Mechanisms, Efficacy, and Clinicals' presentation used to train pharmacy partners, covering all five formulas (FIT, LEAN, ENERGIZED, FOCUSED, HYDRATED) with pathway diagrams, clinical trial data, and patient-facing benefit summaries.

Key Publications
  • BPP Mechanisms, Efficacy & Clinicals — Full Presentation
  • Five-Formula Clinical Education Series for Pharmacy Partners
  • Patient Communication Guide: Bioactive Precision Peptides

MAKE's Pure Promise

Every product in the Bioactive Precision Peptides portfolio meets the highest standards for purity, safety, and efficacy.

NSF Certified
National Sanitation Foundation quality certification
GMP Certified
Good Manufacturing Practice — FDA-registered facilities
Made in USA
Manufactured in domestic, audited facilities
Residue-Free
No heavy metals, pesticides, or contaminants

Ready to Bring This Science to Your Patients?

Partner with Precision Peptide Partners to offer clinically validated, AI-discovered bioactive peptides through your independent pharmacy.