Science & Research
Bioactive Precision Peptides™ are AI-discovered, plant-derived peptides backed by 18+ randomized, double-blind, placebo-controlled clinical trials published in peer-reviewed journals.
AI-Driven Peptide Discovery
MAKE Wellness uses a proprietary machine learning platform to identify bioactive peptides from natural plant sources — 10× faster and 600× more accurate than traditional discovery methods. The AI screens thousands of natural compounds, applies biochemical filters, and validates candidates through a rigorous 6-step process before any human trial begins.
Peptides are information carriers — they carry biological information from one cell to another for everything in the body to function correctly. At least 7,000 peptides are found in the human body, and DNA itself is a matrix of inactive information waiting for peptides to deliver up-regulating or down-regulating messages to genes.
- 1Understand: Determine required biochemical pathways
- 2Identify: Screen for the most effective peptides in nature
- 3Refine: Apply filters to select the best peptides
- 4Confirm: Produce a sample and test on cells
- 5Validate: Unlock the natural network and test on humans
- 6Produce: Patent and produce peptides formulated with synergistic co-factors
The Five Formulas — Mechanisms & Efficacy
Each formula targets a distinct biological pathway. Click any card to expand the full mechanism and clinical benefit breakdown.
Peer-Reviewed Clinical Studies
All human trials listed are randomized, double-blind, and placebo-controlled unless otherwise noted. Full protocols, participant numbers, endpoints, and p-values are available upon request.
Key Researchers
The science behind Bioactive Precision Peptides™ is authored by a team of PhDs and AI researchers whose combined work spans peptide biochemistry, clinical nutrition, machine learning, and pharmaceutical formulation.
Mark Bartlett serves as Chief Scientific Officer at MAKE Wellness, overseeing the scientific integrity and clinical validation of all Bioactive Precision Peptide formulas. He leads the MAKE Wellness science team in ensuring every product meets the highest standards of evidence-based nutrition.
Dr. Bartlett's work spans clinical nutrition, peptide formulation, mTOR pathway activation, and myostatin inhibition — applying a rigorous validation process from biochemical pathway mapping through cell-level confirmation to human clinical trials before any peptide enters a MAKE Wellness formula.
Dr. Bartlett serves as Chief Scientific Officer at MAKE Wellness and is the primary author of the MAKE Wellness clinical research reviews, including the peer-reviewed 'Fit with Peptistrong Plus' and 'Lean with Apticurb Trimfast Complex' papers. His work focuses on translating AI-discovered peptide candidates into clinically validated nutritional formulations, with a particular emphasis on mTOR activation, myostatin inhibition, and metabolic pathway modulation.
- ›Fit with Peptistrong Plus — Clinical Review
- ›Lean with Apticurb Trimfast Complex — Clinical Review
- ›BPP: A New Class of Clinically Validated Nutritional Therapeutics
Dr. Jones serves as Director of Research at MAKE Wellness, specializing in the metabolic and lipolytic mechanisms underlying the LEAN and ENERGIZED formulas. His research examines how bioactive peptides modulate the gut-brain axis — regulating ghrelin, leptin, and NPY — to produce clinically measurable reductions in fat mass without lean muscle loss. He co-authored the BPP clinical studies summary covering 18 randomized controlled trials.
- ›BPP Studies: A New Class of Clinically Validated Nutritional Therapeutics
- ›Metabolic Modulation via Gut-Brain Axis Peptides
- ›Lipolysis Enhancement Through Bioactive Peptide Pathways
Dr. Nora Khaldi is the Founder of Nuritas, a world-leading AI-driven bioactive peptide discovery company that invested over $100 million in R&D. Her proprietary machine learning platform identified the natural peptides used in MAKE Wellness formulas — including Peptistrong Plus and Lean with Apticurb Trimfast Complex. Her work focuses on translating AI-discovered peptide candidates from natural food sources into clinically validated nutritional formulations.
- ›Fit with Peptistrong Plus — Peptide Discovery & Clinical Validation
- ›Lean with Apticurb Trimfast Complex — AI-Identified Natural Peptides
- ›BPP: A New Class of Clinically Validated Nutritional Therapeutics
MAKE's Pure Promise
Every product in the Bioactive Precision Peptides portfolio meets the highest standards for purity, safety, and efficacy.
Ready to Bring This Science to Your Patients?
Partner with Precision Peptide Partners to offer clinically validated, AI-discovered bioactive peptides through your independent pharmacy.